CRP/HDL Ratio (CHL Index) Calculator
- CRP/HDL Ratio (CHL Index): Explanation and Clinical Context
The CRP/HDL Ratio, also known as the CHL Index, is a cardiovascular risk marker derived from the ratio of C-reactive protein (CRP) to high-density lipoprotein cholesterol (HDL-C). CRP is a marker of systemic inflammation, while HDL-C has anti-inflammatory and cardioprotective properties.
A higher CHL Index indicates a greater inflammatory burden relative to protective HDL cholesterol, which is associated with increased risk of atherosclerotic cardiovascular events.
Risk stratification is generally classified as low (<0.5), intermediate (0.5–0.99), and high (> 1.0), based on prospective cohort studies.
This tool allows clinicians to integrate inflammatory status with lipid profile to better identify patients at higher cardiovascular risk.
Reference:
Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002;347:1557-1565. doi:10.1056/NEJMoa021993
Discussion
No discussions yet. Be the first to comment.
Create Note
Notes are stored privately on your device only. No login required. Nothing is uploaded or shared.