Systemic Inflammation Response Index (SIRI) Calculator
- Systemic Inflammation Response Index (SIRI): Explanation and Clinical Context
SIRI is a novel biomarker that quantifies systemic inflammation by integrating neutrophil, monocyte, and lymphocyte counts. It is calculated as (Neutrophil count × Monocyte count) / Lymphocyte count.
This index has been studied for prognostic value in cardiovascular diseases, oncology, and sepsis. A higher SIRI reflects a greater inflammatory state, which is associated with worse clinical outcomes.
SIRI is particularly useful for risk stratification, guiding treatment intensity, and monitoring response to anti-inflammatory therapies.
Reference:
Qi Q, et al. Systemic Inflammation Response Index (SIRI) Predicts Prognosis in Patients With Solid Tumors. Front Oncol. 2016;6:171. doi:10.3389/fonc.2016.00171
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