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Cardiotoxicity Risk by Troponin (TnI, TnT) Calculator

  • Troponin I (ng/mL)
  • Troponin T (ng/mL)
  • Cardiotoxicity Risk by Troponin: Explanation and Clinical Context
    The Cardiotoxicity Risk Calculator estimates the likelihood of developing chemotherapy-induced cardiac dysfunction based on Troponin I (TnI) and Troponin T (TnT) levels. Elevated troponin levels during or shortly after chemotherapy are predictive of subsequent left ventricular dysfunction and heart failure.
    Troponin I <0.04 ng/mL is generally associated with low risk (<5%) of cardiotoxicity, levels between 0.04–0.1 ng/mL indicate intermediate risk (5–20%), and levels >0.1 ng/mL suggest high risk (>20%).
    This tool can help clinicians identify patients who may benefit from early cardioprotective interventions, closer cardiac monitoring, and individualized chemotherapy planning.

    Reference:
    Cardinale D, et al. Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy. Circulation. 2004;109:2749–2754. doi:10.1161/01.CIR.0000125141.25078.05