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DETECT ICD Algorithm (Syncope Work-up)

  • Age (years)
  • Structural heart disease?
  • Left ventricular ejection fraction (LVEF %)
  • ECG abnormality present?
  • Documented ventricular arrhythmia (VT/VF) or prior cardiac arrest?
  • Syncope during exertion, while supine, or without prodrome?
  • Family history of sudden cardiac death (first-degree relative <50 y)?
  • Electrophysiology Study (EPS) abnormal / inducible VT?
  • DETECT ICD algorithm — explanation and clinical context
    The DETECT ICD tool is a pragmatic, rule-based decision support algorithm to help clinicians triage patients with syncope who may require consideration of implantable cardioverter-defibrillator (ICD) therapy or expedited electrophysiology evaluation. It prioritizes: (1) clear secondary-prevention indications such as documented sustained ventricular tachycardia (VT) or cardiac arrest; (2) guideline thresholds for primary prevention (for example structural heart disease with reduced LVEF ≤35% after optimization of medical therapy); and (3) aggregation of high-risk clinical features — abnormal ECG, syncope during exertion or without prodrome, family history of sudden cardiac death, and inducible ventricular arrhythmia on EPS — to identify intermediate and high-risk cases. For patients without high-risk features, the recommended pathway emphasizes targeted diagnostic testing (orthostatic vitals, ECG, ambulatory monitoring or implantable loop recorder, tilt-testing when reflex syncope suspected) and specialist referral when features are concerning. This approach is aligned with contemporary syncope guidelines and validated risk frameworks used for short-term outcome prediction in emergency settings.

    References:
    Brignole M, et al. 2018 ESC Guidelines for the diagnosis and management of syncope. Eur Heart J. 2018;39:1883–1948. doi:10.1093/eurheartj/ehy037.
    Thiruganasambandamoorthy V, et al. Development of the Canadian Syncope Risk Score to predict 30-day serious outcomes after ED assessment of syncope. CMAJ. 2016;188:E289–E298.
    Olshansky B, et al. Sudden death risk in syncope: the role of the implantable cardioverter-defibrillator — review and clinical perspective. (reviewed literature).
    Pezawas T, et al. Unexplained syncope in patients with structural heart disease — role of electrophysiology and ICD consideration. Eur Heart J / Europace (selected studies).