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GLOBAL-LEADERS All-Cause Mortality Subgroup Calculator

  • Age (years)
  • Sex (1=male, 0=female)
  • Diabetes mellitus (1=yes, 0=no)
  • Left ventricular ejection fraction (%)
  • Clinical presentation – ACS (1=yes, 0=no)
  • GLOBAL-LEADERS All-Cause Mortality Subgroup Calculator: Explanation and Clinical Context
    The GLOBAL-LEADERS trial was an open‐label, all‐comers randomized study of 1 month of aspirin + ticagrelor followed by 23 months of ticagrelor monotherapy vs 12 months of DAPT followed by 12 months of aspirin in patients undergoing PCI with a biolimus‐eluting stent. The primary outcome (all-cause mortality or non-fatal myocardial infarction) did not reach statistical superiority. Several subgroup and post-hoc analyses (including all-cause mortality) have been reported, though a fully published risk prediction model for all-cause mortality has not been made publicly available. This calculator uses a simplified logistic model to provide an illustrative estimated risk of 2-year all-cause mortality in a PCI population similar to GLOBAL-LEADERS participants. Clinicians should interpret the result cautiously and in the context of the individual patient.

    Reference:
    Gao C, et al. A post-hoc analysis of the GLOBAL-LEADERS trial. 2020. PMC.

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