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RESTORE-EF Post-Myocarditis Recovery Index

  • Age (years)
  • Baseline LVEF (%)
  • LV end-diastolic diameter (LVEDD, mm)
  • Presence of LGE on CMR?
  • Peak troponin (ng/mL)
  • NT-proBNP (pg/mL)
  • Time from symptom onset to treatment (days)
  • RESTORE-EF Post-Myocarditis Recovery Index: explanation and clinical context
    This page implements a proposed heuristic index to estimate the likelihood of left ventricular ejection fraction (LVEF) recovery after acute myocarditis. The index integrates several clinical and imaging features that have repeatedly been associated with myocardial recovery in published myocarditis and myocardial-injury cohorts: baseline LVEF (higher baseline LVEF associated with better recovery), smaller LV cavity size, absence of late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR), lower peak cardiac troponin, lower natriuretic peptide levels, and earlier initiation of appropriate therapy. The numerical weights in this tool are deliberately transparent and pragmatic (scaled component scores summing to a 0–100 index) so clinicians and developers may adjust or validate them against local data. This index is NOT a validated prediction model and should not be used alone for clinical decision making — it is intended as a reproducible, code-friendly starting point for research, local validation, or incorporation into prospective studies.

    Reference summary: RESTORE-EF as named in the literature generally refers to LVEF improvement after Impella-supported high-risk PCI rather than a myocarditis recovery prediction tool. Determinants of myocardial recovery in myocarditis include baseline systolic function, LV dimensions, presence and extent of myocardial LGE on CMR, and biomarkers such as troponin and natriuretic peptides; these sources informed the choice of candidate variables here. Validation and recalibration using real patient cohorts (with outcomes at defined follow-up times, e.g., 90 days to 6 months) are required to convert this heuristic into a clinically reliable prediction model.

    References: RESTORE EF study summary and results (Impella / HRPCI).
    Key myocarditis recovery literature and determinants of recovery (imaging, LGE, biomarkers).

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