General Cardiovascular Risk Assessment Scores

SCORE2-Diabetes Calculator

Clinical calculation support · Verify results before clinical use

10-Year Cardiovascular Risk Assessment

Enter the patient's clinical and diabetes-related characteristics.

SCORE2-Diabetes

1. Patient characteristics

Age (years)ESC recommended calculation population: 40 years and older; this calculator limits input to 40–69 years.

Sex

Male

Female

Current smoking

Yes

European cardiovascular risk regionSelect only when applying the corresponding European calibration. Indonesia is not assigned to an ESC SCORE2 risk region.

2. Cardiovascular history and target-organ damage

Established atherosclerotic cardiovascular disease (ASCVD)

Yes

Severe target-organ damage (TOD)Includes severe kidney disease/proteinuria or microvascular disease in at least three sites (see definition below).

Patients with established ASCVD or severe TOD are classified as very high cardiovascular risk by ESC criteria; SCORE2-Diabetes risk calculation is not required for this classification.

3. Conventional cardiovascular risk factors

Systolic blood pressure (mmHg)

Total cholesterol

HDL cholesterol

4. Diabetes-specific variables

Age at type 2 diabetes diagnosis (years)

HbA1c

The model uses IFCC mmol/mol. NGSP % is converted internally.

eGFR (mL/min/1.73 m²)Enter a creatinine-based eGFR value.

—10-year risk

ESC cardiovascular risk category

—

Clinical interpretation

Calculation details

About SCORE2-Diabetes

SCORE2-Diabetes estimates the 10-year risk of fatal and non-fatal cardiovascular disease (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in people with type 2 diabetes without previous cardiovascular disease.

The model extends SCORE2 by incorporating diabetes-specific predictors and competing-risk-adjusted, sex-specific equations. Its original calibration is specific to four European cardiovascular risk regions.

Model variables

Domain	Variables
Demographic	Age and sex
Conventional risk	Current smoking, systolic blood pressure, total cholesterol, HDL cholesterol
Diabetes-specific	Age at diabetes diagnosis, HbA1c, eGFR

ESC risk categories

Category	10-year CVD risk
Low	<5%
Moderate	5% to <10%
High	10% to <20%
Very high	≥20%, or established ASCVD/severe TOD

Severe target-organ damage (ESC 2023)

eGFR <45 mL/min/1.73 m², irrespective of albuminuria; or
eGFR 45–59 mL/min/1.73 m² with UACR 30–300 mg/g; or
UACR >300 mg/g; or
Microvascular disease in at least three different sites.

References

SCORE2-Diabetes Working Group and the ESC Cardiovascular Risk Collaboration.SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe. European Heart Journal. 2023;44(28):2544–2556. DOI: 10.1093/eurheartj/ehad260. Includes Supplementary Methods Table 1 with the algorithm and recalibration parameters.

Marx N, Federici M, Schütt K, et al.2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes. European Heart Journal. 2023;44(39):4043–4140. DOI: 10.1093/eurheartj/ehad192.

SCORE2 Working Group and ESC Cardiovascular Risk Collaboration.SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. European Heart Journal. 2021;42(25):2439–2454. DOI: 10.1093/eurheartj/ehab309.

Clinical disclaimer: This calculator is an educational clinical decision-support aid and does not replace clinical assessment or guideline-based decision-making. SCORE2-Diabetes was developed and calibrated for European populations. The four calibration regions are not validated substitutes for Indonesia or other non-European populations. Do not interpret a regional estimate as a locally calibrated absolute risk. Patients with established ASCVD or severe target-organ damage should be classified using the relevant clinical criteria rather than relying on this calculation.