General Cardiovascular Risk Assessment Scores

LIFE-CVD Calculator – Lifetime Cardiovascular Disease Risk

Clinical calculation support · Verify results before clinical use

LIFETIME CARDIOVASCULAR RISK

Estimate lifetime cardiovascular risk

Estimate 10-year and lifetime risk of fatal and non-fatal cardiovascular disease, accounting for competing non-CVD mortality.

Model LIFE-CVD2 (2024) Population Primary prevention Age at entry 35–90 years
PATIENT PROFILE

Enter clinical parameters

All fields required
Model entry age: 35–90 years
Choose the region-specific calibration. This is not an Indonesia-specific calibration.
Convert mg/dL to mmol/L: divide by 38.67
Convert mg/dL to mmol/L: divide by 38.67

Do not calculate if either statement is not true. LIFE-CVD2 is intended for primary prevention in individuals without established CVD or diabetes.

METHODOLOGY & INTERPRETATION

How the calculator works

LIFE-CVD2 uses sex-specific Cox proportional-hazards functions for CVD events and non-CVD mortality. The model uses age as the time axis and combines the two endpoint-specific risks in annual life-table intervals to account for competing risks.

  • Predictors: age, current smoking, systolic blood pressure, total cholesterol, and HDL cholesterol, including age interactions.
  • Age and continuous predictors are centred at 60 years, 120 mmHg, 6 mmol/L total cholesterol, and 1.3 mmol/L HDL cholesterol, respectively.
  • Diabetes coefficients are intentionally excluded from clinical calculation, as instructed by the supplementary material; the model is not intended for people with diabetes.
  • Region-specific recalibration uses the published intercept and slope parameters for CVD events and non-CVD mortality.
Primary reference

Hageman SHJ, et al. Prediction of individual lifetime cardiovascular risk and potential treatment benefit: development and recalibration of the LIFE-CVD2 model to four European risk regions. Eur J Prev Cardiol. 2024;31(14):1690–1699. doi:10.1093/eurjpc/zwae174.

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