Globorisk Cardiovascular Risk Calculator: Comprehensive Explanation and Clinical Context
The Globorisk model estimates the 10-year probability of developing a major cardiovascular event (myocardial infarction, stroke, or cardiovascular death) based on easily available clinical factors such as age, sex, blood pressure, total cholesterol, smoking status, and diabetes. It is designed to be adaptable for various countries by calibrating local incidence rates and risk factor distributions.
Normal interpretation:
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Low risk: <10%
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Moderate risk: 10-20%
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High risk: >20% Clinical significance: Globorisk helps clinicians identify individuals at elevated risk who may benefit from preventive therapy such as statins, antihypertensive medications, or lifestyle modifications. Its calibration flexibility makes it suitable for both developed and developing countries.
Clinical interpretation summary: Globorisk provides a simple, evidence-based, and globally applicable tool to guide cardiovascular prevention strategies at both individual and population levels.
References:
1. Danaei G, et al. Global cardiovascular risk prediction: a novel approach for the estimation of risk and uncertainty in 182 countries. The Lancet Global Health. 2015;3(12):e704-e712.
2. Bennett JE, et al. Globorisk: cardiovascular disease risk prediction for the whole world. The Lancet Global Health. 2021;9(5):e558-e567.
3. Globorisk Project. www.globorisk.org