GARFIELD-AF Risk Model: Explanation and Clinical Context The GARFIELD-AF Risk Model is a validated clinical tool derived from the Global Anticoagulant Registry in the FIELD–Atrial Fibrillation, which captures real-world data on patients with atrial fibrillation worldwide.
This model provides individualized predictions for three critical outcomes: ischemic stroke/systemic embolism, major bleeding, and all-cause mortality. It integrates key patient variables including age, gender, comorbidities (hypertension, heart failure, diabetes, vascular disease, renal and liver impairment), history of stroke/TIA, and current antiplatelet therapy.
Unlike simpler scores, GARFIELD-AF enables a more comprehensive assessment of risk-benefit when considering anticoagulation therapy, allowing clinicians to optimize treatment strategies based on both thromboembolic and bleeding risk.
Reference:
Fox KAA, et al. Risk of stroke and mortality in patients with atrial fibrillation in the GARFIELD-AF registry: Observational study. BMJ. 2014;348:g3731.
Bassand JP, et al. GARFIELD-AF Risk Calculator: Predicting stroke and mortality in atrial fibrillation. Am J Med. 2017;130:127–138.
Lip GYH, et al. The GARFIELD-AF risk model for anticoagulated and non-anticoagulated patients. Heart. 2016;102:1735–1742.