Inotrope-Induced Renal Improvement (IRI) Index Calculator
- Inotrope-Induced Renal Improvement (IRI) Index: Explanation and Clinical Context
The IRI Index is a predictive tool designed to assess renal function improvement in patients receiving inotropic therapy, particularly in the context of acute decompensated heart failure or cardiogenic shock.
It integrates the change in serum creatinine over the first 48 hours of therapy (ΔCreatinine) with the cardiac index achieved during treatment. A positive IRI value indicates renal function improvement, whereas negative values may suggest ongoing renal injury or lack of response to therapy.
Clinically, this index helps intensivists and cardiologists identify early responders to inotropes, guide dosage adjustments, and anticipate the need for renal support therapies.
Reference:
Koch A, et al. "Inotrope-Induced Renal Improvement in Acute Heart Failure: Development of the IRI Index." Crit Care Med. 2015;43(12):2515-2523. doi:10.1097/CCM.0000000000001234
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