LMNA Mutation Risk Score Calculator
- LMNA Mutation Risk Score: Explanation and Clinical Context
The LMNA mutation risk score is a clinical tool developed to predict the 5-year risk of life-threatening ventricular tachyarrhythmias (VTA) in patients with LMNA gene mutations. This score incorporates factors such as sex, presence of non-missense mutations, degree of atrioventricular block, occurrence of non-sustained ventricular tachycardia (NSVT), and left ventricular ejection fraction (LVEF). It aids clinicians in identifying high-risk patients who may benefit from closer monitoring or preventive interventions like implantable cardioverter-defibrillator (ICD) implantation.
Reference:
Rootwelt-Norberg C, et al. Timing of cardioverter-defibrillator implantation in patients with cardiac laminopathies—External validation of the LMNA-risk ventricular tachyarrhythmia calculator. Heart Rhythm. 2022 Dec 6;S1547-5271(22)02686-8. doi: 10.1016/j.hrthm.2022.11.024. Available from: https://www.heartrhythmjournal.com/article/S1547-5271(22)02686-8/fulltext
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