Left Ventricular Diastolic Dysfunction Grade (ASE 2016): Explanation and Clinical Context LV diastolic dysfunction refers to abnormal filling and relaxation of the left ventricle. ASE 2016 recommends an integrative approach using four parameters: E/e' ratio, septal e', TR velocity, and left atrial volume index (LAVI).
Grade I represents impaired relaxation with normal filling pressures, Grade II represents pseudonormal filling with elevated filling pressures, and Grade III indicates restrictive filling with markedly elevated filling pressures.
This classification aids in diagnosis, risk stratification, and management of patients with heart failure and other cardiac conditions.
Reference:
Nagueh SF, Smiseth OA, Appleton CP, et al. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016;29(4):277-314. doi:10.1016/j.echo.2016.01.011