MADIT-II ICD Mortality Benefit Score (MADIT-ICD Benefit Score)
- MADIT-ICD Benefit Score — Explanation and clinical context
The MADIT-ICD Benefit Score (Younis et al., 2021) integrates two competing risk scores to predict the likelihood that a patient with low LVEF will derive survival benefit from a prophylactic implantable cardioverter-defibrillator (ICD). The first component estimates the risk of life-threatening ventricular tachyarrhythmia (VT/VF) using eight clinical predictors (male sex; age <75 years; prior non-sustained VT; resting heart rate >75 bpm; systolic blood pressure <140 mmHg; LVEF ≤25%; prior myocardial infarction; and atrial arrhythmia). The second component estimates the competing risk of non-arrhythmic mortality using seven predictors (age ≥75 years; diabetes mellitus; BMI <23 kg/m²; LVEF ≤25%; NYHA class ≥II; presence of CRT (CRT-D reduces the score); and atrial arrhythmia). In the original derivation each predictor is assigned a point value; the VT/VF score ranges 0–13 and the non-arrhythmic mortality score ranges 1–10. Patients are classified into three benefit groups by combining dichotomized versions of the two scores: Highest benefit = high VT/VF & low non-arrhythmic score; Intermediate = either both low or both high; Lowest benefit = low VT/VF & high non-arrhythmic score. The authors also provide a personalized 0–100 benefit score (higher = greater expected ICD benefit) and an online calculator / conversion table in the manuscript supplement. Clinically, the highest group shows the largest absolute reduction in mortality from ICD therapy at 3 years, intermediate shows smaller benefit, and lowest shows the least; the score is intended to support individualized shared decision-making rather than to replace clinical judgement.
Reference:
Younis A, Goldberger JJ, Kutyifa V, et al. Predicted benefit of an implantable cardioverter-defibrillator: the MADIT-ICD benefit score. Eur Heart J. 2021;42(17):1676–1684. DOI:10.1093/eurheartj/ehaa1057.
Online calculator / implementation: QxMD / institutional calculators and the paper supplement.
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