MR-ProADM Risk Score Calculator

MR-proADM Risk Score: Explanation and Clinical Context
The MR-proADM Risk Score is a biomarker-based tool used to assess the severity and predict clinical outcomes in patients with acute infections, sepsis, or other critical illnesses. MR-proADM (mid-regional pro-adrenomedullin) is a stable fragment of adrenomedullin, a peptide involved in vascular tone regulation and endothelial integrity.
Elevated MR-proADM levels reflect endothelial dysfunction and increased disease severity. Risk stratification based on MR-proADM concentrations allows clinicians to guide early triage decisions, hospitalization needs, and intensive care allocation.
- Low Risk (≤0.87 nmol/L): Outpatient management may be considered.
- Intermediate Risk (0.87–1.5 nmol/L): Hospitalization and monitoring advised.
- High Risk (>1.5 nmol/L): Intensive care and aggressive management recommended.

Reference:
Reinhart K, et al. "Biomarkers in Sepsis: MR-proADM as a Prognostic Indicator." Crit Care. 2012;16:R184. doi:10.1186/cc11512
van der Meer V, et al. "MR-proADM predicts mortality and severity in patients with infection and sepsis." Sci Rep. 2021;11:16336. doi:10.1038/s41598-021-84478-1