Polygenic Risk Score (PRS) for Coronary Artery Disease (CAD-PRS) Calculator
- Polygenic Risk Score (PRS) for Coronary Artery Disease (CAD-PRS): Explanation and Clinical Context
The CAD-PRS quantifies an individual's genetic predisposition to coronary artery disease by summing the weighted effects of multiple single nucleotide polymorphisms (SNPs) identified from genome-wide association studies (GWAS).
Each risk allele contributes a specific weight based on its effect size derived from large-scale population studies.
Individuals are stratified into low, intermediate, or high genetic risk categories, which can complement traditional risk factors for better preventive strategies.
While the PRS is not deterministic, it can guide clinicians in early lifestyle intervention, monitoring, and potential pharmacologic prophylaxis.
Reference:
Khera AV, et al. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat Genet. 2018;50:1219-1224. doi:10.1038/s41588-018-0183-z
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