Post-COVID Thrombotic Risk Composite (D-dimer + Clinical) Calculator
- Post-COVID Thrombotic Risk Composite (D-dimer + Clinical): Explanation and Clinical Context
This calculator applies the IMPROVE-DD model, combining clinical factors with D-dimer elevation (≥2× ULN) to estimate venous thromboembolism (VTE) risk in post-COVID patients.
Clinical Significance:
High scores identify patients who may benefit from extended prophylaxis with rivaroxaban 10 mg daily for 35 days post-discharge (as shown in the MICHELLE trial). Low scores suggest no prophylaxis is needed.
Interpretation:
0–1 = Low risk
2–3 = Moderate risk
≥4 = High risk
References:
Gibson CM, Spyropoulos AC, Cohen AT, et al. TH Open. 2017;1:e56–e65.
Giannis D, Barish MA, Goldin M, et al. Blood. 2021;137:2838–2847.
Ramacciotti E, Agati LB, Calderaro D, et al. Lancet. 2022;399:50–59.
Spyropoulos AC, et al. Res Pract Thromb Haemost. 2021;5:e12596.
Stoneham SM, et al. Br J Haematol. 2020;190:e76–e78.
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