T2 Mapping Edema Index (Myocardial) Calculator
- Inputs (all numeric, use dot for decimals)
- T2 Mapping Edema Index: Explanation and Clinical Context
T2 mapping quantifies myocardial transverse relaxation time (T2) in milliseconds on a pixel-wise basis. Elevated myocardial T2 reflects increased free water and serves as a quantitative index of myocardial edema.
About the parameters:
• T2 (ms): quantitative value representing water content in myocardium.
• Z-score: deviation from local normal mean; abnormal if ≥ +2 SD.
• Myocardium:Skeletal T2 ratio: internal normalization; interpretation depends on site-specific reference.
• T2-weighted SI ratio: historical Lake Louise 2009 parameter; ≥ 2.0 indicates edema.
Clinical interpretation:
• Use site-specific thresholds since vendor, field strength, and sequence affect values.
• Z-score ≥ +2 supports edema and—combined with a T1-based abnormality (native T1, ECV, or LGE)—meets the updated 2018 Lake Louise criteria for active inflammation.
• The SI ratio method remains valid when T2 mapping is unavailable but should be interpreted cautiously.
Reference:
O’Brien AT, et al. T2 mapping in myocardial disease: a comprehensive review. J Cardiovasc Magn Reson. 2022;24:33.
Verhaert D, et al. Direct T2 quantification of myocardial edema in acute myocardial infarction. JACC Cardiovasc Imaging. 2011;4(3):269–278.
Friedrich MG, et al. Cardiovascular magnetic resonance in myocarditis. J Am Coll Cardiol. 2009;53:1475–1487.
Ferreira VM, et al. Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation: Expert Panel Recommendations. J Am Coll Cardiol. 2018;72:3158–3176.
Razzaq S, et al. Inter-scanner comparability of Z-scores for native T1 and T2 mapping. Sci Rep. 2024;14:15890.
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