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ACS MACE 30 Day Risk Stratification Tool

  • Age at presentation (years)
  • Systolic blood pressure (mm Hg)
  • Heart rate (beats per minute)
  • Killip class at presentation
  • Body weight (kilogram)
  • History of diabetes hypertension or angina
  • Anterior ST elevation or left bundle branch block on ECG
  • Time from symptom onset to reperfusion treatment (hours)
  • ACS MACE 30 Day Risk Stratification Tool Explanation and Clinical Context
    This calculator implements the TIMI risk score for ST elevation myocardial infarction to estimate thirty day mortality risk in patients with acute coronary syndrome who present with ST elevation.

    It uses simple clinical variables that are available at the bedside including age systolic blood pressure heart rate Killip class history of diabetes hypertension or angina anterior ST elevation or left bundle branch block body weight and time from symptom onset to reperfusion treatment.

    Each factor contributes a defined number of points and the total score from zero to fourteen is associated with a progressive increase in early mortality so low scores identify patients with very low short term risk while high scores identify patients with substantial risk of death and other major adverse cardiovascular events.

    The American College of Cardiology and American Heart Association acute coronary syndrome guideline recommends validated tools such as the TIMI and GRACE scores to support short term risk assessment and selection of an invasive strategy especially in higher risk patients.

    In practice this tool should complement clinical judgement and shared decision making and it can help guide the level of monitoring consideration of early invasive management and intensity of secondary prevention while remembering that individual patient factors and preferences remain central to treatment decisions.

    References
    Morrow D A Antman E M Charlesworth A et al TIMI risk score for ST elevation myocardial infarction a convenient bedside clinical score for risk assessment at presentation Circulation two thousand volume one hundred two pages two thousand thirty one to two thousand thirty seven.
    Rao S V O Donoghue M L Ruel M et al ACC AHA ACEP NAEMSP SCAI guideline for the management of patients with acute coronary syndromes Journal of the American College of Cardiology two thousand twenty five volume eighty five pages two thousand one hundred thirty five to two thousand two hundred thirty seven.

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