COMPERA 2.0 Risk Model Calculator
- COMPERA 2.0 Risk Model: Explanation and Clinical Context
The COMPERA 2.0 Risk Model is an updated four-strata prognostic system for patients with pulmonary arterial hypertension (PAH), derived from the large COMPERA registry. It refines the previous three-strata model by dividing the intermediate group into two categories: intermediate-low and intermediate-high, enhancing clinical decision-making and treatment targeting.
This model integrates six routinely available clinical, functional, and hemodynamic parameters — WHO functional class, 6-minute walk distance (6MWD), NT-proBNP, right atrial area, right atrial pressure, and cardiac index — to generate a composite mean score ranging from 1 (low risk) to 4 (high risk). Each parameter contributes equally to the overall score. The calculated mean score corresponds to one of four risk categories associated with distinct 1-year mortality rates: low (<2%), intermediate-low (2–7%), intermediate-high (7–20%), and high (>20%).
Clinically, this tool helps physicians assess baseline severity and monitor therapeutic response during follow-up. Patients in the low or intermediate-low risk categories are generally considered stable or improving, while those in intermediate-high or high risk require intensified or advanced therapy such as combination regimens or parenteral prostacyclin, and in selected cases, lung transplantation evaluation.
Reference:
Hoeper MM, et al. Risk assessment in pulmonary arterial hypertension: Revised COMPERA 2.0 model. Eur Respir J. 2022;60(1):2102311.
Galiè N, et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2022;43(38):3618–3731.
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