Cost-Effectiveness of Statin Therapy by Age Risk Model Calculator

Age (years)

Sex

10-year ASCVD risk (%) Use Pooled Cohort Equations or a validated external calculator; enter percentage (e.g., 7.5)

Statin intensity

Assumed RRR (%) Typical defaults: Moderate ≈ 25%; High ≈ 35%

Monthly statin cost (USD)

Annual monitoring cost (USD/year)

Average direct medical cost of one ASCVD event (USD)

QALY loss per ASCVD event

Daily pill disutility (QALY/year)

Excess diabetes risk (%)

QALY loss per year with diabetes

WTP threshold (USD/QALY)

Time horizon (years)

Cost-Effectiveness of Statin Therapy by Age/Risk Model: Explanation and Clinical Context
This calculator implements a transparent, adjustable cost-effectiveness framework for primary-prevention statin therapy anchored to a patient’s 10-year ASCVD risk and therapy intensity.
It estimates absolute risk reduction as baseline risk × RRR and converts events prevented into QALYs. Treatment disutility and excess diabetes risk reduce net QALYs. Costs include drug, monitoring, and offset by events avoided. Outputs: net QALYs, net costs, ICER, NMB, and decision vs WTP threshold.

Reference:
Pandya A, et al. JAMA. 2015;314:142–150.
CTT Collaboration. Lancet. 2012;380:581–590.
Mihaylova B, et al. Heart/BMJ Open-access summary. 2024.
ACC/AHA Guideline background, Pooled Cohort Equations, 2024 update.

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