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Endothelial Dysfunction Post-COVID Index (Biomarker Composite) Calculator

  • LDH (U/L)
  • Creatinine (mg/dL)
  • Platelets (109/L)
  • Age (years) Optional (for age-adjusted EASIX)
  • Optional exploratory biomarkers (enter if available)
  • VWF:Ag (% of normal)
  • Soluble P-selectin (ng/mL)
  • Soluble Thrombomodulin (ng/mL)
  • ICAM-1 (ng/mL)
  • VCAM-1 (ng/mL)
  • D-dimer (mg/L FEU)
  • Endothelin-1 (pg/mL)
  • Syndecan-1 (ng/mL)
  • Endothelial Dysfunction Post-COVID Index (Explanation and Clinical Context)
    This calculator combines validated indices of endothelial stress and an exploratory composite to contextualize post-COVID vascular dysfunction.

    EASIX = LDH × Creatinine / Platelets — initially validated in hematologic and COVID-19 populations. Higher EASIX correlates with worse endothelial activation and outcomes.

    Age-adjusted EASIX (aEASIX-COVID) = EASIX × Age, proposed to improve risk stratification in SARS-CoV-2 infection.

    Exploratory Biomarker Composite integrates endothelial activation markers (VWF:Ag, sP-selectin, sTM, ICAM-1, VCAM-1, D-dimer, Endothelin-1, Syndecan-1) normalized to reference limits, reflecting systemic endothelial stress.

    Clinical Use: Interpret trends in context with imaging, inflammatory, and functional tests. Not diagnostic; for research and clinical insight only.

    References:
    Luft T, et al. Blood. 2021.
    Pérez-García F, et al. J Clin Med. 2021.
    Kalicińska E, et al. Sci Rep. 2021.
    Osburn WO, et al. Front Immunol. 2022.
    Tsiatsiou P, et al. Thromb Res. 2025.
    Ambrosino P, et al. Atherosclerosis. 2022.
    Xu S, et al. Cardiovasc Res. 2023.

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