LAAO CHA2DS2-VASc HAS-BLED Hybrid Index Calculator

Left Atrial Appendage Occlusion (LAAO) – CHA₂DS₂-VASc / HAS-BLED Hybrid Index
Enter patient data. Use 1 = yes / 0 = no for binary fields. Age is in years; Sex is M or F.

Age (years)

Sex (M/F)

Congestive heart failure / LV dysfunction (1)

Hypertension (treated or BP ≥140/90) (1)

Diabetes mellitus (1)

Prior stroke/TIA/thromboembolism (2)

Vascular disease (MI, PAD, aortic plaque) (1)

Uncontrolled hypertension (SBP >160 mmHg) (1)

Abnormal renal function (dialysis, transplant, Cr ≥200 μmol/L) (1)

Abnormal liver function (cirrhosis, bilirubin/enzymes >2× normal) (1)

Stroke history (1)

Bleeding history or predisposition (1)

Labile INR (if on VKA; time in range <60%) (1)

Drugs predisposing to bleeding (antiplatelets/NSAIDs) (1)

Alcohol use (≥8 drinks/week) (1)

LAAO CHA₂DS₂-VASc / HAS-BLED Hybrid Index: Explanation and Clinical Context
This calculator combines stroke and bleeding risk scores to guide consideration of left atrial appendage occlusion (LAAO). Patients with high CHA₂DS₂-VASc (≥2 in men, ≥3 in women) and high HAS-BLED (≥3) are typical candidates for LAAO, especially when oral anticoagulation (OAC) poses excessive bleeding risk. The tool supports decision-making but does not replace clinical judgment. Final decisions should integrate patient preferences, anatomy, and contraindications.

References:
Pison L, et al. Europace. 2015. Left atrial appendage closure indications and outcomes.
Streb W, et al. Kardiol Pol. 2020. Prognostic use of CHA₂DS₂-VASc and HAS-BLED after LAAO.
Aarnink EW, et al. JACC Cardiovasc Interv. 2024. Stroke despite anticoagulation and LAAO outcomes.
Sigusch HH, et al. Scand Cardiovasc J. 2025. Comprehensive review of LAAO indications and outcomes.
Morrone D, et al. J Clin Med. 2020. Combined CHA₂DS₂-VASc and HAS-BLED components in AF prognostication.