MR-proADM Index Calculator
- MR-proADM Index: Explanation and Clinical Context
Midregional proadrenomedullin (MR-proADM) is a stable fragment of adrenomedullin precursor, a peptide involved in vasodilation, endothelial function, and cardiovascular homeostasis.
It serves as a biomarker for cardiovascular and sepsis-related risk, reflecting disease severity and predicting adverse outcomes.
Clinical studies have shown that MR-proADM levels correlate with prognosis in patients with heart failure, acute coronary syndrome, and sepsis.
Risk stratification based on MR-proADM (nmol/L):
- < 0.75 nmol/L: Low risk
- 0.75–1.5 nmol/L: Intermediate risk
- > 1.5 nmol/L: High risk
This index helps clinicians identify patients at higher risk for adverse cardiovascular events and mortality, guiding monitoring intensity and therapeutic decisions.
Reference:
Schuetz P, Christ-Crain M, Morgenthaler NG, et al. Mid-regional pro-adrenomedullin improves risk stratification in patients with community-acquired pneumonia. Eur Heart J. 2010;31:2907-2916. doi:10.1093/eurheartj/ehq204
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Appcardio may contain errors. Always verify the calculation and its accuracy before clinical use.