Systolic Pressure Recovery Index (Post-PE Healing) Calculator
- Systolic Pressure Recovery Index (Post-Pulmonary Embolism Healing): Explanation and Clinical Context
The Systolic Pressure Recovery Index (SPRI) is a hemodynamic ratio used to evaluate right ventricular and pulmonary arterial recovery after acute pulmonary embolism (PE). It quantifies the degree of pressure normalization across the pulmonary circulation, specifically reflecting how systolic and diastolic pressures re-equilibrate during convalescence.
A higher SPRI indicates a more favorable reduction in systolic pressure relative to mean pressure, suggesting improved right ventricular–pulmonary artery coupling and decreased vascular resistance following thrombus resolution or recanalization. Conversely, a low SPRI (<0.4) may suggest residual pulmonary vascular obstruction, impaired compliance, or developing chronic thromboembolic pulmonary hypertension (CTEPH).
In clinical follow-up, serial measurement of SPRI can complement echocardiographic indices such as tricuspid annular plane systolic excursion (TAPSE) and right ventricular systolic pressure (RVSP), offering an integrated assessment of post-PE hemodynamic healing.
Reference:
1. Kim NH, Delcroix M, Jenkins DP, et al. Chronic thromboembolic pulmonary hypertension. J Am Coll Cardiol. 2013;62(25 Suppl):D92–D99.
2. Piazza G, Goldhaber SZ. Chronic thromboembolic pulmonary hypertension. N Engl J Med. 2011;364:351–360.
3. van der Hulle T, et al. Hemodynamic recovery after acute pulmonary embolism: implications for right ventricular function and prognosis. Eur Respir J. 2017;49(3):1601787.
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