Vaccination-Associated Cardiac Adverse Event (CAE) Triage Score Calculator
- Age (years)
- Sex (1=Male, 0=Female/Other)
- Days since most recent vaccination
- Dose number (1=first, 2=second, 3+=booster)
- Chest pain present (1=Yes, 0=No)
- Troponin (multiple of local 99th % ULN) (e.g., 0.8, 1.5, 5)
- ECG ST/T changes compatible with myocarditis/pericarditis (1=Yes, 0=No)
- Documented arrhythmia (PVCs, NSVT, VT/VF, atrial arrhythmia) (1=Yes, 0=No)
- Left ventricular ejection fraction (LVEF, %) (if unknown, enter 55)
- CRP (mg/L)
- Fever (≥38°C) within 48h of symptom onset (1=Yes, 0=No)
- Vaccination-Associated Cardiac Adverse Event (CAE) Triage Score: Explanation and Clinical Context
This calculator provides a pragmatic, evidence-informed triage score to guide the initial assessment of suspected vaccine-associated myocarditis or pericarditis. It integrates demographic, temporal, clinical, biomarker, ECG, and imaging variables commonly linked to post-vaccination cardiac adverse events.
While not a validated diagnostic tool, it reflects current expert consensus and published observations, aiding clinicians in structured risk stratification and triage. A high score should trigger emergency-level evaluation and cardiology consultation, while a low score suggests outpatient monitoring if symptoms persist.
References:
Centers for Disease Control and Prevention. Myocarditis after COVID-19 Vaccination: Clinical Considerations. CDC, 2025.
Jain SS, et al. Cardiac manifestations and outcomes of vaccine-associated myocarditis in the young (MACoV). eClinicalMedicine (Lancet). 2024.
Sandeep N, et al. Myocarditis After COVID-19 Vaccination in Pediatrics. JAHA. 2022;11:e026097.
ACC Expert Consensus Decision Pathway on Myocarditis. JACC. 2025.
Parmar K, et al. Cardiac Adverse Events after Vaccination—Systematic Review. Vaccines. 2022;10:722.
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