25(OH)D Level–CV Mortality Index: Explanation and Clinical Context The 25(OH)D Level–CV Mortality Index estimates the 10-year risk of cardiovascular mortality based on circulating 25-hydroxyvitamin D concentrations.
Lower serum 25(OH)D levels have been associated with higher cardiovascular mortality, with risk stratification as follows: <10 ng/mL = very high risk, 10–19 ng/mL = high risk, 20–29 ng/mL = moderate risk, > 30 ng/mL = low risk.
This tool is useful for clinicians to identify patients who may benefit from vitamin D optimization as part of cardiovascular risk management.
Reference:
Zittermann A, et al. Vitamin D deficiency and mortality risk in cardiovascular disease: a meta-analysis of prospective studies. J Clin Endocrinol Metab. 2010;95:3010–3019. doi:10.1210/jc.2010-0033