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ESC Immunotherapy-Related Myocarditis Score Calculator

  • Active Thymoma
  • Cardiomyositis Symptoms
  • ECG QRS Voltage
  • Left Ventricular Ejection Fraction (LVEF)
  • Troponin Elevation
  • ESC Immunotherapy-Related Myocarditis Score: Explanation and Clinical Context
     The ESC Immunotherapy-Related Myocarditis Score is a prognostic tool developed to assess the risk of severe outcomes in patients with immune checkpoint inhibitor (ICI)-associated myocarditis. This score incorporates five key clinical parameters: presence of active thymoma, cardiomyositis symptoms, low QRS voltage on ECG, left ventricular ejection fraction (LVEF) <50%, and elevated troponin levels. A higher score correlates with an increased risk of severe events, such as arrhythmias, heart failure, and cardiomyotoxicity-related death. Clinicians can utilize this score to stratify patients and guide management decisions, potentially identifying those who may be safely managed with less aggressive interventions.

    Reference:
    Power JR, et al. Immune checkpoint inhibitor-associated myocarditis: a novel risk score. Eur Heart J. 2025;ehaf315. doi:10.1093/eurheartj/ehaf315

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