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Global Longitudinal Strain Early Change Index (GLS-ECI) Calculator

  • Baseline GLS (%)
  • Follow-up GLS (%)
  • Global Longitudinal Strain Early Change Index (GLS-ECI): Explanation and Clinical Context
    The Global Longitudinal Strain Early Change Index (GLS-ECI) is a sensitive echocardiographic measure used to detect early myocardial dysfunction before overt changes in left ventricular ejection fraction occur.
    It is calculated as the percentage change between baseline GLS and follow-up GLS: GLS-ECI (%) = (Follow-up GLS − Baseline GLS) / |Baseline GLS| × 100.
    A higher negative change (larger absolute reduction in GLS) indicates early subclinical myocardial injury, commonly used in patients undergoing cardiotoxic chemotherapy or at risk of heart failure.
    GLS-ECI allows clinicians to detect myocardial dysfunction early and implement cardioprotective strategies promptly.

    Reference:
    Thavendiranathan P, et al. Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer therapy. J Am Coll Cardiol. 2014;63(25 Pt A):2751-2768. doi:10.1016/j.jacc.2014.01.073

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