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ICOS Biomarker Model Calculator

  • Troponin (ng/L)
  • BNP (pg/mL)
  • Global Longitudinal Strain (%)
  • ICOS Biomarker Model: Explanation and Clinical Context
     The ICOS Biomarker Model integrates cardiac biomarkers and echocardiographic parameters to assess the risk of cardiotoxicity in cancer patients. Elevated levels of troponin (>16 ng/L) and BNP (>100 pg/mL), along with a reduced global longitudinal strain (<-18%), are indicative of increased risk. This model aids clinicians in early identification and management of patients at high risk for cardiotoxicity.

    Reference:
    Meessen JMTA, et al. Circulating biomarkers and cardiac function over 3 years after chemotherapy with anthracyclines: the ICOS-ONE trial. Eur J Heart Fail. 2020;22(5):900-909. doi:10.1002/ehf2.12695

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