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MADIT-CRT Response Calculator

  • Sex (Female=1, Male=0)
  • Non-Ischemic Etiology (Yes=1, No=0)
  • Left Bundle Branch Block (LBBB) (Yes=1, No=0)
  • QRS Duration >150 ms (Yes=1, No=0)
  • Prior HF Hospitalization (Yes=1, No=0)
  • Left Ventricular End-Diastolic Volume >125 mL/m² (Yes=1, No=0)
  • Left Atrial Volume <40 mL/m² (Yes=1, No=0)
  • MADIT-CRT Response Score: Explanation and Clinical Context
    The MADIT-CRT Response Score is a clinical tool developed to predict the likelihood of a favorable response to cardiac resynchronization therapy with defibrillator (CRT-D) in patients with heart failure and mild symptoms. The score is based on seven baseline clinical and echocardiographic variables: female sex, non-ischemic etiology, left bundle branch block (LBBB), QRS duration >150 ms, prior hospitalization for heart failure, left ventricular end-diastolic volume >125 mL/m², and left atrial volume <40 mL/m².

    A higher score indicates a greater likelihood of a positive response to CRT-D, which is associated with improved survival and reduced hospitalization for heart failure. Conversely, a lower score suggests a reduced benefit from CRT-D, highlighting the importance of patient selection in CRT therapy.

    Reference:
    Goldenberg I, Moss AJ, Hall WJ, et al. Predictors of response to cardiac resynchronization therapy in the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT). Circulation. 2011;124(14):1527-1536. doi:10.1161/CIRCULATIONAHA.110.014324

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