Pulmonary Vasoreactivity Test Response Prediction Model (AVT Response Predictor)

Age (years)

Sex

PAH Subtype

Right Atrial Pressure (RAP, mmHg)

Mean Pulmonary Artery Pressure (mPAP, mmHg)

Pulmonary Capillary Wedge Pressure (PCWP/PAWP, mmHg)

Cardiac Output (CO, L/min)

Optional: NT-proBNP (pg/mL)

Optional: RDW (%)

Optional (for classification of an actual test, not prediction):
Provide values measured during AVT (e.g., with iNO) if available

mPAP during AVT (mmHg)

CO during AVT (L/min)

Pulmonary Vasoreactivity Test Response Prediction Model: Explanation and Clinical Context
This tool integrates a heuristic pre-test probability of a positive acute vasoreactivity test (AVT) response with established adult response criteria (Sitbon and Barst). Classic AVT response is defined by a ≥10 mmHg fall in mPAP to ≤40 mmHg without a drop in cardiac output (Sitbon), or ≥20% decrease in both mPAP and PVR with unchanged or increased CO (Barst/Rich). The pre-test estimation favors idiopathic/heritable PAH, younger age, lower baseline mPAP and RAP, higher CO, lower PVR, and lower NT-proBNP or RDW. Use this tool to aid decision-making and counselling; not as a substitute for guideline-based evaluation.

References
Chin KM, et al. Eur Respir J. 2024;64(4):2401325.
Langleben D, et al. Pulm Circ. 2017;7(1):7–16.
Halliday SJ, et al. J Heart Lung Transplant. 2015;34(3):312–318.
Caicedo L, et al. Pulm Circ. 2019;9(4):2045894019857533.
Kurzyna M, et al. Postepy Kardiol Interwencyjnej. 2015.
Tonelli AR, et al. Respir Med. 2010;104(4):593–600.
Xi Q, et al. Clin Chim Acta. 2015;447:95–98.
Tea I, et al. Methodist DeBakey Cardiovasc J. 2021;17(4):64–74.

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