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CPX-AUC Index (Total Oxygen Uptake Area) Calculator

  • VO₂ at rest (mL/kg/min)
  • VO₂ at anaerobic threshold (mL/kg/min)
  • Peak VO₂ (mL/kg/min)
  • Exercise duration (minutes)
  • CPX-AUC Index (Total Oxygen Uptake Area): Explanation and Clinical Context
    CPX-AUC Index represents the integrated total oxygen uptake during a cardiopulmonary exercise test (CPX). It provides a global measure of aerobic capacity and cardiorespiratory fitness, considering not only peak VO₂ but also submaximal oxygen consumption throughout exercise.
    This index is typically calculated using trapezoidal integration of VO₂ values measured at rest, at anaerobic threshold (AT), and at peak exercise over total exercise duration. It captures the cumulative oxygen exposure, reflecting both the efficiency and endurance of the cardiovascular and muscular systems.
    Normal values vary by age, sex, and fitness level, but higher AUC generally correlates with better functional capacity and lower cardiovascular risk.
    Clinically, CPX-AUC is useful for assessing exercise tolerance, monitoring therapy response, and predicting prognosis in heart failure and other cardiopulmonary conditions.

    Reference:
    Guazzi M, et al. "Cardiopulmonary Exercise Testing: Physiology, Pathophysiology, and Clinical Applications." Circulation. 2009;119:270-287. doi:10.1161/CIRCULATIONAHA.108.793586

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