VE/VCO2 Slope Calculator
- VE/VCO2 Slope (Ventilatory Efficiency Index): Explanation and Clinical Context
VE/VCO2 slope is a measure derived from cardiopulmonary exercise testing (CPET) that quantifies the relationship between minute ventilation (VE) and carbon dioxide output (VCO2) during incremental exercise.
It reflects ventilatory efficiency and can indicate abnormal pulmonary ventilation, increased dead space, or poor perfusion–ventilation matching often seen in heart failure, pulmonary hypertension, and other cardiopulmonary conditions.
Normal values are usually <30; higher slopes are associated with worse prognosis in heart failure and pulmonary hypertension.
Clinically, VE/VCO2 slope is used for risk stratification, exercise prescription, and prognostic evaluation in patients undergoing CPET.
Reference:
Guazzi M, et al. Circulation. 2005;112:3117-3123. doi:10.1161/CIRCULATIONAHA.105.546309
Arena R, et al. Eur Heart J. 2007;28:2020-2028. doi:10.1093/eurheartj/ehm205
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